Feng Wang,Matthew S. Tremblay,Travis Young,Nicole Alvarez,Yan Liu,Juanjuan Du,Peter G. Schultz
申请号：
US15756296
公开号：
US10501546B2
申请日:
2016.09.02
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Disclosed herein are immunoglobulin fusion proteins comprising an insulin therapeutic peptide and an immunoglobulin region that targets the insulin therapeutic peptide to the liver of an individual in need thereof. Further disclosed herein are compositions comprising the immunoglobulin fusion proteins and methods for using the immunoglobulin fusion proteins for the treatment or prevention of a disease or condition in a subject, for example, diabetes and diabetes related conditions.
