Method of treating a patient suffering from colon cancer characterized by the simultaneous administration of BIBW2992 and BIBF1120, and pharmaceutical compositions and kits suitable relates to a process for their preparation, in the process, the present invention is, BIBF1120 is continually in the process administration in accordance with medication administration every day, BIBW2992 be administered in accordance with intermittent administration of medication management weekly.本発明は、BIBF1120及びBIBW2992の同時投与を特徴とする大腸がんを罹患する患者の治療方法、及び本方法に好適な医薬組成物及びキット、その調製方法に関し、前記方法において、BIBF1120は継続的毎日投与投薬管理に従い、BIBW2992は週単位の断続的投与投薬管理に従い投与する。