PROBLEM TO BE SOLVED: To provided an amino alcohol derivative having a synapse formation stimulating activity, low in toxicity and having an improve histological migration property, a pharmaceutically permissible salt thereof, and a medicine containing the derivative or the salt, especially a therapeutic agent or a brain protecting agent for neurological diseases. SOLUTION: An amino alcohol derivative expressed by the formula (1) [wherein, * expresses an asymmetric carbon and R expresses the residue of a carboxylic acid derivative shown by the following (1) to (3): (1) a (poly) glycine residue of (COCH2NH)mZ (m is 1-3 Z is a protecting group for an amino group or an alkanoyl group) (2) a carboxylic acid derivative residue shown by COWY (W is an alkylene or a cycloalkylene Y is OH, a monosaccharide residue, an aryl, an alkoxyl or the like) and (3) the residue of a dicarboxylic acid or its derivative shown by COWCOX W is an alkylene or a cycloalkylene X is OH, an alkoxyl, an alkyl, an &alpha-amino acid residue or NR1R2 (R1 and R2 are each H, an alkyl, a hydroxyalkyl or the like)}] or a pharmaceutically permissible salt thereof.
