Novel methods for reduction or elimination the incidence of hot flushes, vasomotor symptoms, and night sweats while decreasing the risk of acquiring breast , uterine or endometrial cancer and furthermore having beneficial effect by inhibiting the development of osteoporosis, hypercholesterolemia, hyperlipidemia, atherosclerosis, hypertension, insulin resistance, diabetes type 2, loss of muscle mass, adiposity, Alzheimer’s disease, loss of cognition, loss of memory, or vaginal dryness in susceptible warm-blooded animals including humans involving administration of an amount of a sex steroid precursor, particularly dehydroepiandrosterone (DHEA) and an antiestrogen or a selective estrogen receptor modulator, particularly compounds having the general structure:Pharmaceutical compositions for delivery of active ingredient(s) and kit(s) useful to the invention are also disclosed.用於在包括人類在內之易感染的溫血動物中減少或消除熱潮紅、血管舒縮症狀及夜汗之發生同時降低罹患乳癌、子宮癌或子宮內膜癌之風險及更藉由抑制骨質疏鬆症、高膽固醇血症、高脂血症、動脈粥狀硬化、高血壓、胰島素抗性、第2型糖尿病、肌肉耗失、肥胖症、阿滋海默氏(Alzheimer)症、認知喪失、失憶或陰道乾燥之發生而具有有利效應之新穎方法，其涉及投予一量之一種性類固醇前驅物特別是去氫表雄固酮(DHEA)與一種抗雌激素或一種選擇性雌激素受體調節物特別是具有下列通式結構之化合物：亦揭露用於輸送適用於本發明的活性成分與套組之藥學組成物。
