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Compound inhibitors of Metallo Enzymes
专利权人:
INC.;VIAMET PHARMACEUTICALS
发明人:
WILLIAM HOEKSTRA,CHRISTOPHER YATES,MICHAEL R. LOSO,MICHAEL T. SULLENBERGER,ZACHARY A. BUCHAN,ROBERT J. SCHOTZINGER
申请号:
ARP120102182
公开号:
AR088130A1
申请日:
2012.06.19
申请国别(地区):
AR
年份:
2014
代理人:
摘要:
Pharmaceutical components and antifungal components of plants 1. Claim 1: a formula compound (1),Or a salt, wherein MBG is a selective substitute for tetrazoline, a substitute for triazoline, a substitute, a substitute, a substitute pyridine, a substitute, a substitute triazole, or a substitute pyridine, a substitute pyridine; R1 is h, halogen, asphalt or halogen; R2 is h, halogen, asphalt or halogen; R3 is Independent forms: H, asphalt, nitric acid, cyanogen, halogen, halogen, Alcoy, halo, halocalcoy, alquenilo, halo alquilo, halocclo, halocclo, hexacyclo, tar, halogenil, tioalquilo, sf-8323;SF832626,SCN SO R-C (O) -alkyl, -C (O) OH, -C (O) O-alkyl, C (O) H, CH = N-O-alkyl, -CH = N-O-arylalkyl; R⁴ is aryl, heteroaryl or cycloalkyl optionally substituted with 0, 1, 2 or 3 independent R³; R⁵ is alkyl, haloalkyl, cycloalkyl, alkenyl C₂₋₈,1. C 83228331 asphalt;a. Arilo, heatarilo, arilalquilo, O heterosexual, each of which is replaced by 0, 12 or 3 cubic meters; r8310s is tar, arilo, which is replaced by arilo, heterosexual or heterosexual; r8311es h, tar, - Si (r831222) c8323;-P (O) (OH)-CH -O-P (O) (OH)O-C (o) - asphalt substituted by ammonia; r831222 is independent asphalt or arilo; r8313 is independent h, asphalt, halogen or halide; X is or s;Composición farmacéutica y composición antifúngica para plantas. Reivindicación 1: Un compuesto de fórmula (1), o una sal del mismo, donde: MBG es tetrazolilo opcionalmente sustituido, triazolilo opcionalmente sustituido, oxazolilo opcionalmente sustituido, pirimidinilo opcionalmente sustituido, triazolilo opcionalmente sustituido, o pirazolilo opcionalmente sustituido; R¹ es H, halo, alquilo o haloalquilo; R² es H, halo, alquilo o haloalquilo; R³ es en forma independiente H, alquilo, nitro, ciano, haloalquilo, alcoxi, halo, haloalcoxi, alquenilo, haloalquenilo, cicloalquilo, halocicloalquilo, alquinilo, haloalquinilo, tioalquilo, SF₃, SF₆, SCN, SO₂R⁶, -C(O)-alquilo, -C(O)OH, -C(O)O-alquilo, C(O)H, CH=N-O-alquilo, -CH=N-O-aril
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