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dental material containing magnetic nanoparticle-anchored metalloproteinases inhibitors to reduce degradation of dentin organic matrix
专利权人:
UNIVERSIDADE FEDERAL DO CEARÁ
发明人:
DAVINO MACHADO ANDRADE NETO,MADIANA MAGALHÃES MOREIRA,PIERRE BASÍLIO ALMEIDA FECHINE,VICTOR PINHEIRO FEITOSA,WALTER ZENOBI
申请号:
BR102017012174
公开号:
BR102017012174A2
申请日:
2017.06.08
申请国别(地区):
BR
年份:
2018
代理人:
摘要:
Dental material containing magnetic nanoparticle - anchored metalloproteinases inhibitors to reduce the degradation of the dentin organic matrix, materials to inhibit dentinal metalloproteinases (mmps) are used as dentin treatment after dentin demineralization in order to preserve its collagen. however, inhibitors that have been studied to date have a temporary efficacy, since they release mmps over the years and allow them to be free and activated, thus being able to degrade the dentin organic matrix. With the use of magnetic nanoparticle-anchored mmps inhibitors, the inhibitors can interact with the nimpis and then be attracted to an outer magnetic field. Thus, the mmijs are permanently removed, resulting in the control of caries progression, erosion and stabilization of the adhesive interface due to the reduction of the degradation of the dentin organic matrix. With the present invention, the state of the art of dentin treatment materials (inhibition of minaps) is modified to an innovative and conservative technique based on the rapid, safe and effective removal of mmps, which mediates the degradation of almost all matrix proteins. as extracellular dentin collagen.material odontologico contendo inibidores de metaloproteinases ancorados em nanopartículas magnéticas para redução da degradação da matriz orgânica dentinaria, materiais para inibição de metaloproteinases (mmps) dentináriassão utilizados como tratamento dentinário após a desmineralização da dentina com a finalidade de preservar o colágeno desta. entretanto, os inibidores até hoje estudados possuem eficácia temporária, pois liberam as mmps ao longo dos anos e permitem que estas voltem a estar livres e ativadas, sendo assim capazes de degradar a matriz orgánica dentinária. com a utiázaçao de inibidores de mmps ancorados em nanopartículas magnéticas, os inibidores podem interagir com as nimpis e, em seguida, serem atraídos por um campo magnético exterior. dessa forma, as mmijs são removidas de forma defini
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