SAHA, Saurabh,WELSCH, Dean,DECRESCENZO, Gary,ROIX, Jeffrey James
申请号：
EP17800334
公开号：
EP3458056A4
申请日:
2017.05.22
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The present invention provides, inter alia, methods, pharmaceutical compositions, and kits for treating or ameliorating the effects of a cancer in a subject, which cancer is refractory or resistant to non-ERK MAPK pathway inhibitor therapy. Also provided are methods for identifying a subject having cancer who would benefit from therapy with an ERK inhibitor and methods for inhibiting phosphorylation of RSK in a cancer cell that is refractory or resistant to a non-ERK MAPK pathway inhibitor.
