Saurabh Saha,Dean Welsch,Gary DeCrescenzo,Jeffrey James Roix
申请号：
US15797593
公开号：
US20180104228A1
申请日:
2017.10.30
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides, inter alia, methods, pharmaceutical compositions, and kits for treating or ameliorating the effects of a cancer in a subject, which cancer is refractory or resistant to non-ERK MAPK pathway inhibitor therapy. Also provided are methods for identifying a subject having cancer who would benefit from therapy with an ERK inhibitor and methods for inhibiting phosphorylation of RSK in a cancer cell that is refractory or resistant to a non-ERK MAPK pathway inhibitor.
