SAHA, SAURABH,WELSCH, DEAN,DECRESCENZO, GARY,ROIX, JEFFREY JAMES
申请号：
CA3024703
公开号：
CA3024703A1
申请日:
2017.05.22
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention provides, inter alia, methods, pharmaceutical compositions, and kits for treating or ameliorating the effects of a cancer in a subject, which cancer is refractory or resistant to non-ERK MAPK pathway inhibitor therapy. Also provided are methods for identifying a subject having cancer who would benefit from therapy with an ERK inhibitor and methods for inhibiting phosphorylation of RSK in a cancer cell that is refractory or resistant to a non-ERK MAPK pathway inhibitor.
