GEIERSTANGER, BERNHARD HUBERT,GRUNEWALD, JAN,BURSULAYA, BADRY
申请号：
CA2873998
公开号：
CA2873998A1
申请日:
2013.05.31
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present disclosure provides methods of site-specific labeling of antibodies, using proteins having 4'-phosphopantetheinyl transferase activity that catalyze post-translational modification of peptide sequences ("peptide tags") incorporated into one or more specific sites of an antibody of interest. Enzymatic labeling enables quantitative and irreversible covalent modification of a specific serine residue within the peptide tags incorporated into the antibody, and thus creates desirable antibody conjugates.
