Jan Grunewald;Badry Bursulaya;Bernhard Hubert Geierstanger
发明人:
Bernhard Hubert Geierstanger,Jan Grunewald,Badry Bursulaya
申请号：
US13906584
公开号：
US09585970B2
申请日:
2013.05.31
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention provides methods of site-specific labeling of antibodies, using proteins having 4′-phosphopantetheinyl transferase activity that catalyze post-translational modification of peptide sequences (“peptide tags”) incorporated into one or more specific sites of an antibody of interest. Enzymatic labeling enables quantitative and irreversible covalent modification of a specific serine residue within the peptide tags incorporated into the antibody, and thus creates desirable antibody conjugates.
