LOZOYA TORIBIO MARIA ESTRELLA,MATASSA VICTOR GIULIO,MIR CEPEDA MARTA,ROBERTS RICHARD SPURRING,VIDAL JUAN BERNAT,EASTWOOD PAUL ROBERT,GOMEZ CASTILLO ELENA,GONZALEZ RODRIGUEZ JACOB
申请号：
ARP120102585
公开号：
AR087211A1
申请日:
2012.07.17
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
The present relates to compounds of formula (1), the procedure for preparing such Compounds, their use in the treatment of Pathological condition or disease that could improve activity of CRTH2 antagonist, and a Pharmaceutical composition useful in allergic Respiratory Diseases Cas and cardiovascular.Claim 1: a compound of formula (1) or a pharmaceutically acceptable Salt, solvate or stereoisomer, N oxide, the deuterated derivative: or, where X represents a nitrogen Atom, Z represents a carbon Atom and represents a nitrogen Atom or group or a few； X represents a carbon Atom.Z is a nitrogen Atom and represents a nitrogen Atom or a few Group； r1 is selected from the group consisting of a hydrogen Atom and a linear or branched alkyl group C1 - 4； each of R2, R3, R4 and R5 are selected independently from the group consisting of an Atom Mo Hydrogen, a Halogen Atom, a linear or branched alkyl group C1 - 4A cycloalkyl Group C3 - 7, a group haloalquilo linear or branched C1 - 4, - CN Group, An - Oh Group, a group or a Group - CO2H co2ra, a Group, a Group, and a Group so2ra； g is selected from the group consisting of a phenyl Group and a heteroaryl Group 5 to 6 Members that contains n,Where the phenyl heteroaryl groups are optionally substituted with one or more substituents selected from the group consisting of an atom of halogen, a cyano Group, a Nitro Group, a group CHF2 - Cf3 Group, an alkyl group, a linear or branched C1 - C3 - 4, a cycloalkyl Group 7 - Oh, a Group, or a Group,A Group - and a Group so2ra； R6 is selected from the group consisting of a group N (R7) - C (o) - R8, a group N (R7) so2r8 a heteroaryl Group selected from the group consisting of a Group triazolilo isoxazolilo, a Group, a group and a Group oxazolilo pirazolilo,Where is optionally substituted heteroaryl Group with one or more substituents selected from the group consisting of a Halogen Atom, - Cf3 Group, a linear or branched alkyl Group 4 C1 - C3 - 7, a cycloalkyl Group, a benzyl Group, a phenyl G
