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Nanoparticle-peptide compositions
专利权人:
Midatech Limited
发明人:
Rademacher, Thomas,Williams, Phillip
申请号:
AU2012306243
公开号:
AU2012306243B2
申请日:
2012.09.07
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
The present invention provides nanoparticles and compositions comprising such nanoparticles, as well as methods for intracellular delivery of peptides, and methods of producing nanoparticles and related products. The nanoparticles comprise a core comprising a metal and/or a semiconductor atom; and a corona comprising a plurality of ligands covalently linked to the core, wherein at least a first ligand of said plurality comprises a carbohydrate moiety that is covalently linked to the core via a first linker, and wherein at least a second ligand of said plurality comprises a peptide of choice that is covalently linked to the core via a second linker. The second linker comprises a peptide portion and a non- peptide portion, wherein said peptide portion of said second linker comprises the sequence X
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