Sarah Hamm-Alvarez,John Andrew MacKay,Guoyong Sun,Pang-Yu Hsueh
申请号：
US13764476
公开号：
US20130210747A1
申请日:
2013.02.11
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Disclosed herein are novel methods and compositions for targeting drug delivery systems to specific cells. One aspect relates to a drug delivery system comprising an elastin-like peptide (ELP) component and a ligand selected from the group consisting of mIgA and knob capable of either drug encapsulation or drug attachment. Further aspects relate to drug delivery systems comprising an elastin-like peptide (ELP) component and a ligand； wherein the ligand specifically binds to a receptor selected from the group consisting of CAR and pIgR. Further aspects include the novel transcytosing properties of the elastin-like peptide and the ligand, knob. Also provided are methods and pharmaceutical compositions comprising the disclosed therapeutics.
