SOLUTION: There is provided a granulation composition comprising nuclear particles, coated particles, and a binder for coupling nuclear particles, coupling the nuclear particles and coated particles for forming a shape of particle, the coated particles are adhered to the surrounding of the granulation body formed of the nuclear particles and the binder, the coated particles are insoluble to the binder, the nuclear particles and/or binder include drug efficient component or biological functional component, and a development area ratio Sdr of a boundary surface is 100-700.EFFECT: It is possible to stably acquire a granulation body whose surface is covered with coated particles, which has uniform property and which is hardly segregated even when a binder is a thin solution with weak gel strength, and by setting a gelatinizer density of the binder to a low density for making the binder the thin solution, the excellent characteristics of the granulation composition can be achieved.SELECTED DRAWING: Figure 1COPYRIGHT: (C)2020,JPO&INPIT【解決手段】核粒子と、被覆粒子と、前記核粒子同士及び前記核粒子と前記被覆粒子とを結合して粒状の形体を保持する結合剤とを具備し、前記核粒子と結合剤とからなる造粒物本体の周囲に前記被覆粒子が付着してなり、前記被覆粒子が前記結合剤に不溶なものであり、前記核粒子及び／又は結合剤に薬効成分又は生体機能性成分が含有され、かつ界面の展開面積比Ｓｄｒが１００～７００であることを特徴とする造粒組成物を提供する。【効果】結合剤がゲル強度の弱い希薄な溶液であっても、表面が被覆粒子で覆われた均一で、かつ偏析し難い造粒物を安定的に得ることができ、上記結合剤のゲル化剤濃度を低く設定して希薄な溶液とすることによって、この優れた特性を有する造粒組成物を生産性よく製造することができる。【選択図】図１
