PROBLEM TO BE SOLVED: To provide a composition capable of securing long term stability even if dextrin is not contained, the composition containing nanoparticles of low molecular-weight heparin and protamine.SOLUTION: The invention provides a production method of an agent containing nanoparticles containing LMWH and protamine (LMWH/P NPs), the method comprising adding a diluted protamine solution to a diluted LMWH solution with a physiological salt solution and stirring it.SELECTED DRAWING: Figure 1COPYRIGHT: (C)2016,JPO&INPIT【課題】 デキストリンを含有しなくても長期安定性を担保可能な、低分子ヘパリンとプロタミンのナノ粒子を含有する組成物の提供。【解決手段】 生理食塩水を用いた希釈LMWH溶液に希釈プロタミン溶液を添加及び撹拌する工程を含む、LMWHとプロタミンとを含むナノ粒子(LMWH/P NPs)を含有する剤の製造方法。【選択図】 図1
