The present invention relates to a process of producing a nano-CBD microemulsion system includes: (i) preparing a dispersal phase by dissolving CBD in an ethanol solvent in a ratio between mass of CBD:volumn of ethanol solvent as 8:10 at a speed of 300 to 500 rpm with heating to a temperature ranging from 40 to 60° C. within 4 to 8 hours； (ii) preparing a carrier by heating a liquid PEG (polyethylene glycol) accounted for 40-60% by mass of the mixture of PEG and water to a temperature from 60 to 80° C., stirring homogeneously； (iii) adding the carrier to the dispersal phase in a ratio by mass of 40:60, continuing heating the dispersal phase to a temperature of 40 to 60° C., stirring at a speed of 400 to 800 rpm； (iv) elmusifying as follows: when the temperature arrives at 100° C., adding ACRYSOL K-140 to the mixture of the carrier and dispersal phase obtained in step (iii) in a ratio by mass of 40:60, continuing to stir at a speed of 500 to 700 rpm, at a temperature of about 100° C., in vacuum, the reaction temperature is kept at 100° C. for 3 to 5 hours, controlling the quality of resulting products until it is transparent, the reaction is quenched, the temperature is decreased slowly until it is in the range of 40 to 60° C.； emulsifing the entire mixture for 30 minutes, at a speed of 400 to 800 rpm. (v) filtrating the products by injecting through nanofilters before filling-packaging.
