The present invention relates to a process of producing a nano-CBD liposomesystem comprises: (i) preparing a dispersal phase by dissolving CBD in anethanolsolvent in a ratio between mass of CBD:volumn of ethanol solvent as 8:10 by astirrerat a speed of 300 to 500 rpm and simultaneously heating to a temperatureranging from40 to 60°C within 4 to 8 hours； (ii) preparing a liposome carrierconsisting of lecithin,olive oil in a ratio by mass of 1:3 mixed in a themostatic bath at atemperature from 40to 60°C to ensure that lecithin completely dissolves in oil, stirringhomogeneously；(iii) adding the carrier to the dispersal phase in a ratio by mass of 40:60,continuingheating the dispersal phase to a temperature ranging from 40 to 60°C,stirring at aspeed of 800 to 1000 rpm for 1 to 2 hours； (iv) cooling the resulting mixtureto 25°Cand injecting one volumn of distilled water between 1 and 1.5 L by using hight-frequencynozzles at a frequency of 60 Hz, drop sizes ranging from 10 to 20 pm,injecting capacity of 10 ml/ min, with the temperature of distilled water of25°C,giving a liposome suspension - water solution； (v) homogenizing the mixture ofliposome suspension - water solution by injecting through 30 Mpa high pressurehomogenizers to obtain a nano-CBD liposome system which is a homogeneous,stablemixture ensured with the particle sizes <；200 nm.
