PROBLEM TO BE SOLVED: To obtain a nicotine transdermal absorption preparation has excellent content uniformity, satisfies both fixedness and a soft feeling during adhesion, has reduced skin irritation upon peeling off and excellent adhesive property and to provide a method for simply and economically producing a nicotine transdermal preparation, which has excellent nicotine coating uniformity in a production process and produces the preparation.SOLUTION: The method for producing a nicotine transdermal absorption preparation comprises forming an adhesive layer containing a liquid component compatible with nicotine and an adhesive on a substrate and has (1) a process for making an adhesive layer containing a liquid component compatible with an adhesive in which the contact angle of nicotine to the adhesive layer before nicotine addition is 20-60° and (2) a process for coating the adhesive layer with nicotine and impregnating the adhesive layer with nicotine. The nicotine transdermal absorption preparation is obtained by forming an adhesive layer containing a liquid component compatible with nicotine and an adhesive on a substrate. The contact angle of nicotine to the adhesive layer before nicotine addition is 20-60°.COPYRIGHT: (C)2007,JPO&INPIT【課題】含量均一性に優れ、貼付時の固定性とソフト感を両立し、剥離時の皮膚刺激が低減された粘着物性に優れたニコチン経皮吸収製剤の提供。製造工程においてニコチン塗布均一性に優れ、上記製剤を提供できる、簡便かつ経済的なニコチン経皮吸収製剤の製造方法の提供。【解決手段】支持体上に、ニコチン及び粘着剤と相溶する液状成分を含む粘着剤層が形成されたニコチン経皮吸収製剤の製造方法であって、(1)粘着剤と相溶する液状成分を含有する粘着剤層であって、ニコチン含有前の粘着剤層に対するニコチンの接触角が20~60°である粘着剤層を提供する工程、及び、(2)ニコチンを該粘着剤層に塗布し、ニコチンを粘着剤層中に含浸させる工程を含む方法。支持体上に、ニコチン及び粘着剤と相溶する液状成分を含有する粘着剤層が形成されたニコチン経皮吸収製剤であって、ニコチン含有前の粘着剤層に対するニコチンの接触角が20~60°である製剤。【選択図】なし
