NOUVEAUX CONJUGUÉS CONTENANT TÉTRAGALNAC ET PEPTIDE ET PROCÉDÉS POUR L'ADMINISTRATION D'OLIGONUCLÉOTIDES

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专利权人:

SIRNA THERAPEUTICS; INC.

发明人:

TELLERS, DAVID,COLLETTI, STEVEN, L.,DUDKIN, VADIM,AARONSON, JEFFREY,MOMOSE, AARON,TUCKER, THOMAS, JOSEPH,YUAN, YU,CALATI, KATHLEEN, B.,TIAN, LU,PARMAR, RUBINA, G.,SHAW, ANTHONY, W.,WANG, WEIMIN,STORR,

申请号：

EP13784726

公开号：

EP2844662A4

申请日:

2013.05.01

申请国别(地区):

EP

年份:

2015

代理人:

摘要：

Disclosed herein is a modular composition comprising 1) an oligonucleotide； 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different； optionally, 3) one or more linkers, which may be the same or different； 4) one or more peptides independently selected from Table 3, which may be the same or different； and optionally, 5) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.

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中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/