Methods of treating pain associated with osteoarthritis of a joint in a mammal with a pharmaceutical composition comprising a spiro-oxindole compound of the formula:are disclosed. The methods provide excellent penetration of the spiro-oxindole compound into the synovial membrane of the affected joint to effectively reduce the severity of the pain and/or to alleviate the pain with minimal or negligible systemic exposure.本文揭示用包含下式之螺-吲哚酮化合物之醫藥組合物治療哺乳動物之與關節之骨關節炎相關的疼痛之方法,該等方法提供該螺-吲哚酮化合物至受影響關節之滑膜中之極佳滲透,以在極小或可忽略不計之全身性暴露下有效降低該疼痛之嚴重度及/或緩和該疼痛。