Michael Fetell,Richard Malamut,Michael J. Lamson,Ofer Spiegelstein,Charles Jay Cohen,Yigal Paul Goldberg,Rostam Namdari,Nicola Anne Price,Katie Jane Webster Proctor
申请号：
US14614895
公开号：
US20150216794A1
申请日:
2015.02.05
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Methods of treating pain associated with osteoarthritis of a joint in a mammal with a pharmaceutical composition comprising a spiro-oxindole compound of the formula:are disclosed. The methods provide excellent penetration of the spiro-oxindole compound into the synovial membrane of the affected joint to effectively reduce the severity of the pain and/or to alleviate the pain with minimal or negligible systemic exposure.
