A measurement device and method for measuring psychology stress index and blood pressure is disclosed. When the measurement device is in the psychology stress measurement mode and a pressurizing motor unit is pressurizing an airbag unit with a variable speed, the micro-processor unit may control the pressurizing motor unit to stop pressurizing the airbag unit after the pressure signal is determined as a pulse signal, and the micro-processor unit may measure the pulse signal to determine the psychology stress index. The psychology stress index is a ratio of SDNN and RMSSD according to interval data of the pulse signal within a period of time.