The United States of America; as represented by the Secretary; Department of Health and Human
发明人:
Xuejun Chen,Jeffrey Boyington,Hongying Duan,Cheng Cheng,John R. Mascola
申请号：
US16496912
公开号：
US20200121783A1
申请日:
2018.03.26
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Embodiments of immunogens based on the outer domain of HIV-1 gp120 and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to prime an immune response to gp120 in a subject, for example, to treat or prevent an HIV-1 infection in the subject.
