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3,7-DIAZABICYCLO[3.3.1]NONANE CARBOXAMIDES AS ANTITHROMBOTIC AGENTS
专利权人:
发明人:
申请号:
EP14759059.0
公开号:
EP3052498A1
申请日:
2014.07.09
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
The present invention relates to the 3,7-diazabicyclo[3.3.1]nonane carboxamides and process for preparation thereof. The present invention further relates to the compounds of general formula 1 possessing anti-thrombotic (anti-platelet) activities. The invention also relates to use of these moieties as inhibitors of collagen induced platelet adhesion and aggregation mediated through collagen receptors both in vitro and in vivo. Further, invention also relates these class of compounds exhibiting anti-platelet efficacy through dual mechanism inhibited both collagen as well as U46619 (thromboxane receptor agonist) induced platelet aggregation. wherein, R′ is wherein R is selected from alkyl, acyl, tosyl, tert-butyloxycarbonyl, araalkyl or substituted araalkyl groups R″ is selected preferably from halogen, cyano, lower alkyl, aryl, substituted aryl, and tosyl groups R1 is selected from hydrogen and lower alkyl groups R2 is selected from lower alkyl and aryl groups R3 is selected from tert-butyloxycarbonyl and bezyloxycarbonyl groups n=0,1.
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