KUMPF, Robert Arnold,MCALPINE, Indrawan James,MCTIGUE, Michele Ann,PATMAN, Ryan,RUI, Eugene Yuanjin,TATLOCK, John Howard,TRAN-DUBE, Michelle Bich,WYTHES, Martin James
申请号：
PE2018003140
公开号：
PE20190439A1
申请日:
2017.06.03
申请国别(地区):
PE
年份:
2019
代理人:
摘要：
Is the compound of formula (I),Or a pharmaceutically acceptable salt, wherein R1 is selected from the non biological hydrogen Xi group of 5-12 members； R2 is hydrogen, halogenation, etc.； each R8 either does not exist or is selected separately from the non biological hydrocarbon groups of 5-12 members (C1-C8)； Each R9 is hydrogen or fluorination (independent)；D is O, s, among other things； G is an isomerized ring system of (c5-c12) arilo or 5-12 members, combined with ring system (C3-C10) or isomerized ring system； q is absent, or the isomerized part selected from O, s, NH and (C1-C8) tar； V is n or C (if Z is now)；W is n or C, X is n or C (yes and now)；He's not, among other things, N, or s, not, N, or something. In addition to the pharmacological composition containing at least one compound of the invention (which may be combined with one or more compounds other than the invention), it may also be associated with one or more precursors or acceptable carriers on the drug (according to factors such as management mode, influence of precursors on solubility and stability, etc.). It also refers to the preparation process of compounds, including the use of their pharmacological components,There are also treatments for abnormal cell growth in mammals (such as cancer). The current invention is useful for the treatment of mammalian abnormal cell growth, such as cancer.Se refiere a compuestos de la Formula (I), o una sal de estos aceptable desde el punto de vista farmaceutico, en donde R1 se selecciona del grupo que consiste en hidroxi, heteroarilo de 5-12 miembros, entre otros； R2 es hidrogeno, halogeno, entre otros； cada R8 esta ausente o se selecciona de forma independiente entre heteroarilo de 5-12 miembros, (C1-C8)haloalquilo, entre otros； cada R9 es hidrogeno o fluor (de forma independiente)； D es O, S, entre otros； G es un (C5-C12)arilo o un sistema de anillos de heteroarilo de 5-12 miembros, fusionado a un sistema de anillos de (C3-C10)cicloalquilo o heterociclilo；
