USE OF HUMANIZED MICE TO DETERMINE TOXICITY
- 专利权人:
- MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- 发明人:
- BOUGUERMOUH, SALIM,KHOURY, MAROUN,CHEN, QINGFENG,CHEN, JIANZHU
- 申请号：
- EP20120854884
- 公开号：
- EP2788758(A4)
- 申请日:
- 2012.12.05
- 申请国别(地区):
- 欧洲专利局
- 年份:
- 2015
- 代理人:
- 摘要：
The invention is directed to a method of determining whether an agent causes immune toxicity in a human comprising administering the agent to a non-human mammal that has been engrafted with human hematopoietic stem cells (HSCs) and administered one or more human cytokines; and determining whether the agent causes immune toxicity in the non-human mammal. If the agent causes immune toxicity in the non-human mammal then the agent causes toxicity in a human. The invention is also directed to a method of determining whether administration of an agent causes cytokine release syndrome in an individual in need thereof comprising administering the agent to a non-human mammal that has been engrafted with HSCs and administered one or more human cytokines; and determining whether the agent causes cytokine release syndrome in the non-human mammal. If the agent causes cytokine release syndrome in the non-human mammal then the agent will cause cytokine release syndrome in the human.
- 来源网站：
- 中国工程科技知识中心
