The invention relates to a method and to devices for determining interaction forces between substrates, for example, material surfaces, and test bodies, such as particles, cells, agglomerates, which can be solid, deformable, or liquid. According to the invention, the interaction forces are measured by means of analytical centrifugation. The composite "substrate-adhering bodies" is subjected to a defined ascending centrifugal acceleration, and the failure of the composite is detected automatically and touch-free by means of a detection system during the centrifugation. According to the invention, this is achieved either directly by temporal reduction of the quantity (number) of the bodies adhering to the substrate or, on the other hand, the increase in quantity of the detached bodies at a position located radially further outwards is realized and quantified by a quantity-sensitive detection method. The detection devices can be integrated into the rotor, but can also be mounted entirely or partially outside the
