PROBLEM TO BE SOLVED: To provide an antibody useful for treating a disease in which a systemic residence time is required for a specific purpose. SOLUTION: The first variant Fc region polypeptide and the first variant Fc region polypeptide, in which the FcRn binding property is altered by altering the amino acid residue at the non-corresponding position in each Fc region polypeptide, are modified. An IgG class Fc region containing an IgG class Fc region comprising the variant 2 Fc region polypeptide, an antibody containing the IgG class Fc region, and a pharmaceutical preparation containing the antibody. [Selection diagram] Figure 1【課題】特定の目的に合わせた全身滞留時間が必要とされる疾患の治療に有用な抗体の提供。【解決手段】個々のFc領域ポリペプチド中の非対応位置のアミノ酸残基を改変することによって、FcRn結合特性が変更された変種Fc領域が変更された、第1の変種Fc領域ポリペプチドと第2の変種Fc領域ポリペプチドとを含むIgGクラスFc領域を含むIgGクラスFc領域、該IgGクラスFc領域を含む抗体、および該抗体を含む薬学的製剤。【選択図】図１
