LUPIN LTD.;ARORA, SUDERSHAN, KUMAR;SRIVASTAVA, VANDITA;ADDEPALLI, VEERANJANEYULU;NATESAN, SRIDHAR;GOEL, RAJAN
发明人:
ARORA, SUDERSHAN, KUMAR,SRIVASTAVA, VANDITA,ADDEPALLI, VEERANJANEYULU,NATESAN, SRIDHAR,GOEL, RAJAN
申请号：
WO2003IN00289
公开号：
WO2004019960(A2)
申请日:
2003.08.27
申请国别(地区):
世界知识产权组织国际局
年份:
2004
代理人:
摘要：
A pharmaceutical composition comprising a herbal extract, comprising a mixture of saponins prepared from the pericarp of Sapindus trifoliatus, with binding affinities for the receptor sites viz. GABA-A agonist site, Glutamate-AMPA site, Glutamate-Kainate site, Glutamate-NMDA agonistic site, Glutamate-NMDA glycine (strychnine insensitive) site and Sodium channel (site 2). having major mediatory role in anticonvulsant activity. A process for preparation of the herbal extract; isolation of six pure compounds from the mixture of saponins in the aqueous extract; and a pharmaceutical composition comprising the said extract in combination with pharmaceutically acceptable additives. A method of prophylactic treatment of migraine through anticonvulsant activity of the composition by its administration through intranasal route.
