LERCHEN HANS-GEORG,LINDEN LARS,EL SHEIKH SHERIF,WILLUDA JOERG,KOPITZ CHARLOTTE CHRISTINE,SCHUHMACHER JOACHIM,GREVEN SIMONE,MAHLERT CHRISTOPH,STELTE-LUDWIG BEATRIX,GOLFIER SVEN,BEIER RUDOLF,HEISLER IRI
申请号：
IN8497/DELNP/2013
公开号：
IN2013DN08497A
申请日:
2013.09.30
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The present application relates to novel anti C4 4a binder drug conjugates (ADCs) of N N dialkyl auristatins to effective metabolites of said ADCs to methods for producing said ADCs to the use of said ADCs for treating and/or preventing diseases and to the use of said ADCs for producing pharmaceuticals for treating and/or preventing diseases in particular hyperproliferative and/or angiogenic diseases such as cancers. Such treatments can be carried out as monotherapy or in combination with other pharmaceuticals or additional therapeutic measures.
