The present invention relates to an automatic medicine packing machine for packing a variety of medicines dose by dose continuously. According to the present invention, there is provided an automatic medicine packing machine for packing a variety of medicines dose by dose continuously, comprising: a plurality of cassette units (2) in which the variety of medicines are accommodated a hopper (4) for collecting the medicines discharged from the cassette units (2) a packing unit (5) for packing the medicines collected by the hopper (4) and a shutter assembly (6) mounted on the hopper (4) to temporarily suspend the medicines discharged from the cassette units (2), wherein the shutter assembly (6) includes a frame (10) detachably mounted to an upper end of the hopper (4) an openable/closable shutter unit (20) arranged and mounted on the frame (10) a driving means (31,32) for driving the shutter unit (20) to be opened and closed and an interlocking unit (40) for transferring a driving force of the driving means (31,32) to the shutter unit (20) to interlock the shutter unit (20).
