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ORALLY ADMINISTERED ADSORBENT, THERAPEUTIC AGENT FOR RENAL DISEASE, AND THERAPEUTIC AGENT FOR LIVER DISEASE
专利权人:
KUREHA CORPORATION
发明人:
NAOHIRO SONOBE,TAKASHI WAKAHOI,TAKAHIRO AKITA
申请号:
US14767971
公开号:
US20150374743A1
申请日:
2014.02.24
申请国别(地区):
US
年份:
2015
代理人:
摘要:
An object of the present invention is to provide an orally administered adsorbent capable of adsorbing large quantities of tryptophan or indoxyl sulfate in the presence of bile acid. The problem can be solved by an orally administered adsorbent comprising spherical active carbon having bulk density from 0.30 to 0.46 g/mL, specific surface area determined by the Brunauer-Emmett-Teller (BET) method of not less than 2000 m2/g, total acid group content of less than 0.30 meq/g, pore volume of pore diameter from 20 to 10,000 nm of not more than 0.21 mL/g; and a micropore volume ratio (Vm) of not less than 1.0, determined by Formula (1): Vm=(V2.0−V1.1)/(V1.1−V0.64) (1) [in Formula (1), V2.0, V1.1, and V0.64 are cumulative pore volumes of pore diameters not greater than 2.0 nm, not greater than 1.1 nm, and not greater than 0.64 nm, respectively, calculated by the SF method from nitrogen adsorbed quantity].
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