Achim DOERNER,Lars TOLEIKIS,SOOD D. Vanita,Carolin SELLMANN,Christine KNUEHL
申请号：
US15773555
公开号：
US20180326085A1
申请日:
2016.10.27
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A heterodimeric bispecific immunoglobulin molecule includes a first Fab or scFv fragment which specifically binds to EGFR, and a second Fab or scFv fragment which specifically binds to c-MET, and an antibody hinge region, an antibody CH2 domain and an antibody CH3 domain including a hybrid protein-protein interaction interface domain. Each of the interaction interface domains is formed by an amino acid segment of the CH3 domain of a first member and an amino acid segment of the CH3 domain of a second member. The hybrid protein-protein interface domain of the first chain is interacting with the protein-protein-interface of the second chain by homodimerization of a corresponding amino acid segment of the same member of the immunoglobulin superfamily within interaction domains.
