Emory University;Children's Healthcare of Atlanta, Inc.
发明人:
H. Trent Spencer,Christopher B. Doering,Brantley R. Herrin,Max Dale Cooper
申请号：
US16400501
公开号：
US20190256574A1
申请日:
2019.05.01
申请国别(地区):
US
年份:
2019
代理人:
摘要：
This disclosure relates to recombinant cellular expression of chimeric proteins with peptide sequences derived from lymphocyte receptors and uses for treating cancer. In certain embodiments, the disclosure relates to a recombinant vector comprising a nucleic acid that encodes a chimeric protein with a segment with a targeting moiety based on a variable lymphocyte receptor (VLR) capable of binding a tumor associated antigen and a segment with a T cell signal transduction subunit. In certain embodiments, the recombinant vectors are used in immune based cancer treatments.
