COMPOSITIONS AND METHODS FOR T-CELL AND CYTOKINE ACTIVATION

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专利权人:

The Regents of the University of Michigan

发明人:

Challice Bonifant

申请号：

US16358253

公开号：

US20190284288A1

申请日:

2019.03.19

申请国别(地区):

US

年份:

2019

代理人:

摘要：

Chimeric antigen receptors (CARs) are provided that comprise a CD123-specific antigen recognition domain and IL7Ra transmembrane and intracellular signaling domains (CD123/IL7Ra CARs). In particular embodiments, provided herein are engineered lymphocytes that express and display CD123/IL7Ra CARs, and methods of targeting CD123-positive leukemic cells and treating leukemias, such as acute myeloid leukemia (AML), therewith.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/