Challice L. Bonifant,Alnawaz Rehemtulla,David M. Markovitz
申请号：
US16782417
公开号：
US20200247868A1
申请日:
2020.02.05
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The disclosure provides a chimeric antigen receptor (CAR) polypeptide having an antigen binding domain comprising an extracellular lectin which specifically binds to glycoproteins expressed on the surface of target cells. Also provided herein are engineered lymphocytes expressing the CAR polypeptide, a nucleic acid molecule encoding the CAR polypeptide, and methods of treating cancer.
