DADD, CHRISTOPHER,STENLAND, CHRISTOPHER J.,KENT, JONATHAN D.,KORNEYEVA, MARINA N.,BAUMBACH, GEORGE A.,COOK, SCOTT A.,BRADLEY, RITA T.,NOVOKHATNY, VALERY,VILLINES, TANETTE B.
申请号：
CA2389487
公开号：
CA2389487C
申请日:
2000.11.13
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Disclosed is both a process for producing a reversibly inactive acidifiedplasmin by activating plasminogen and a process for producing a purifiedplasminogen. The produced plasmin is isolated and stored with a low pH-buffering capacity agent to provide a substantially stable formulation. Thepurified plasminogen is typically purified from a fraction obtained in theseparation of immunoglobulin from Fraction II + III chromatographic processand eluded at a low pH. The reversibly inactive acidified plasmin may be usedin the administration of a thrombolytic therapy.
