Jeffrey A. Yuziuk;James F. Rebbeor;Jonathan S. Strauss
发明人:
James F. Rebbeor,Jonathan S. Strauss,Jeffrey A. Yuziuk
申请号：
US12399438
公开号：
US08268782B2
申请日:
2009.03.06
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Disclosed is both a method for preparing a plasminogen and a method for preparing a reversibly inactive acidified plasmin by activating the plasminogen. The prepared plasminogen is typically purified from a fraction obtained in the separation of immunoglobulin from Fraction II+III chromatographic process and eluted at a low pH. The prepared plasmin is isolated and stored with a low pH-buffering capacity agent to provide a substantially stable formulation. The reversibly inactive acidified plasmin may be used in the administration of a thrombolytic therapy.
