PROBLEM TO BE SOLVED: To provide a climacteric disorder improving agent, food and drink, and supplement which are free from risk of adverse effect, and ameliorating symptoms which occur in the period of climacteric disorder.SOLUTION: Grape seed extract contains various catechins such as a monomer of flavan-3-ol, a gallate-type of monomer of flavan-3-ol, an oligomer of flavan-3-ol and a gallate-type of oligomer of flavan-3-ol, and climacteric disorder improving agent, food and drink, and supplement having the grape seed extract of the present invention as a major component are effective for preventing intestinal bacterial flora from becoming bad which occurs in the period of climacteric disorder, and ameliorating weight gain symptom and reducing symptom of glucose tolerance which are caused by intestinal bacterial flora becoming bad.SELECTED DRAWING: Figure 1COPYRIGHT: (C)2018,JPO&INPIT【課題】副作用のリスクのない更年期障害期に生じる症状を軽減する更年期障害改善剤、飲食物、サプリメント提供することを課題とする。【解決手段】ブドウ種子抽出物には、フラバン-3-オールのモノマー、フラバン-3-オールのモノマーのガレート型、フラバン-3-オールのオリゴマー、およびフラバン-3-オールのオリゴマーのガレート型といった種々のカテキン類が含まれ、本件発明のブドウ種子抽出物を主要成分とする更年期障害改善剤、飲食物、サプリメントは、更年期障害期に生じる腸内細菌叢の悪玉化を抑制し、腸内細菌叢の悪玉化に起因する体重増加症状、及び耐糖能の低下症状を軽減するために有効である。【選択図】図1
