System of the present invention is closed the composition of the aqueous solvent extract for the seed that one kind contains shaddock and the aqueous solvent extract of profound rice and is treated or inhibited the various symptoms of skin puzzlement or the method for the allergic skin diseases comprising Atopic dermatitis using the composition.本發明係關於一種含有柚子之種子之水性溶劑萃取物及玄米之水性溶劑萃取物之組合物、以及使用該組合物治療或抑制肌膚困擾之各種症狀或包含異位性皮膚炎之過敏性皮膚疾病之方法。