Inhibition of SOX9 function fn the treatment of proteogl ycan-associated pathophysiological conditions

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专利权人:

The University of Western Ontario

发明人:

Gris, Paul,Brown, Arthur

申请号：

AU2007308716

公开号：

AU2007308716B2

申请日:

2007.10.25

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

A method of treating a pathophysiological condition caused by the production ofgrowth-inhibiting proteoglycans is provided. It is based on the finding that down-regulationof SOX9 results in decreased production of growth-inhibiting factors such asproteoglycans, and increased production of growth-promoting factors suchas a laminin and fibronectin. The method of the present invention comprises theinhibition of SOX9 expression and function with an inhibitor such as an antisenseoligonucleotide or a siRNA.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/