Inhibition of SOX9 function in the treatment of proteoglycan-associated pathophysiological conditions

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专利权人:

Paul Gris;Arthur Brown

发明人:

Arthur Brown,Paul Gris

申请号：

US12447238

公开号：

US08791084B2

申请日:

2007.10.25

申请国别(地区):

US

年份:

2014

代理人:

摘要：

A method of treating a pathophysiological condition caused by the production of growth-inhibiting proteoglycans is provided. It is based on the finding that down-regulation of SOX9 results in decreased production of growth-inhibiting factors such as proteoglycans, and increased production of growth-promoting factors such as a laminin and fibronectin. The method of the present invention comprises the inhibition of SOX9 expression and function with an inhibitor such as an antisense oligonucleotide or a siRNA.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/