SOULAGEMENT DE TROUBLES À L'AIDE D'AGENTS DE COMBINAISON QUI AUGMENTENT LES ACIDES GRAS ÉPOXYGÉNÉS ET D'AGENTS QUI AUGMENTENT LE MONOPHOSPHATE D'ADÉNOSINE CYCLIQUE

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专利权人:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人:

HAMMOCK, BRUCE, D.,INCEOGLU, A., BORA,JINKS, STEVEN, L.

申请号：

EP09813652

公开号：

EP2334180A4

申请日:

2009.09.11

申请国别(地区):

EP

年份:

2013

代理人:

摘要：

The present invention relates to compositions and methods for promoting and enhancing the analgesic, anesthetic and anticonvulsant properties of epoxygenated fatty acids, in particular, epoxy-eicosatrienoic acids (&ldquo；EETs&rdquo；) and inhibitors of soluble epoxide hydrolase (&ldquo；sEH&rdquo；) in the presence of elevated levels of cyclic adenosine monophosphate (&ldquo；cAMP&rdquo；) by combining or co-administering the epoxygenated fatty acid, EET and/or inhibitor of sEH with an agent that increases intracellular levels of cAMP, e.g., a phosphodiesterase inhibitor.

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