David J. Maloney,Andrew S. Rosenthal,Ajit Jadhav,Thomas S. Dexheimer,Anton Simeonov,Zhihao Zhuang,Qin Liang,Diane K. Luci
申请号：
US14655538
公开号：
US09802904B2
申请日:
2013.12.26
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Disclosed are inhibitors of the USP1/UAF1 deubiquitinase complex, for example. of formula (I), wherein R1, R2, and Q are as defined herein, which are useful in treating diseases such as cancer, and improving the efficacy of DNA damaging agents in cancer treatment. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least one compound of the invention, a method of method of inhibiting a heterodimeric deubiquitinase complex in a cell, and a method of enhancing the chemotherapeutic treatment of cancer in a mammal undergoing treatment with an anti cancer agent. Further disclosed is a method of preparing compounds of the invention.
