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用於對腦內所蓄積的TAU蛋白質進行成像的新的化合物
专利权人:
NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES
发明人:
HIGUCHI MAKOTO,SUHARA TETSUYA,MARUYAMA MASAHIRO,CHO MEIEI,SHIMADA HITOSHI,樋口真人,須原哲也,丸山將浩,張明榮,島田齊
申请号:
HK15109324.1
公开号:
HK1208672A
申请日:
2015.09.23
申请国别(地区):
HK
年份:
2016
代理人:
摘要:
The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof. wherein: R 1 and R 2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R 3 is hydrogen or halogen; ring A is a benzene ring or a pyridine ring; ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv): in the formula (ii), R a is alkyl; R 4 and R 5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; and represents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain.
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中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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