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NOVEL COMPOUND FOR IMAGING TAU PROTEIN ACCUMULATED IN THE BRAIN
专利权人:
National Institute of Radiological Sciences
发明人:
Higuchi, Makoto,Suhara, Tetsuya,Maruyama, Masahiro,Cho, Meiei,Shimada, Hitoshi
申请号:
AU2015101580
公开号:
AU2015101580A4
申请日:
2015.10.26
申请国别(地区):
AU
年份:
2015
代理人:
摘要:
#$%^&*AU2015101580A420151203.pdf#####Abstract The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof. [Formula 1] R3 R4 N R5 5 Formula (1) wherein: Ri and R2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl R3 is hydrogen or halogen 10 ring A is a benzene ring or a pyridine ring ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv): [Formula 2] R, and 15 in the formula (ii), Ra is alkyl R4 and R5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl and[Formula 3] represents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain. 5
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