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Novel Compounds for Imaging Tau Proteins That Accumulate in the Brain
专利权人:
National Institutes for Quantum and Radiological Science and Technology
发明人:
Makoto Higuchi,Tetsuya Suhara,Masahiro Maruyama,Meiei Cho,Hitoshi Shimada
申请号:
US16798226
公开号:
US20200262829A1
申请日:
2020.02.21
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof.wherein:R1 and R2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl;R3 is hydrogen or halogen;ring A is a benzene ring or a pyridine ring;ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv):in the formula (ii), Ra is alkyl;R4 and R5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; and[Formula 3]represents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain.
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