Torsten B. MEISSNER,Leonardo M.R. FERREIRA,Jack L. STROMINGER,Chad A. COWAN
申请号：
HK18113328
公开号：
HK1254190A1
申请日:
2018.10.18
申请国别(地区):
HK
年份:
2019
代理人:
摘要：
Disclosed herein are universal donor stem cells and related methods of their use and production. The universal donor stem cells disclosed herein are useful for overcoming the immune rejection in cell-based transplantation therapies. In certain embodiments, the universal donor stem cells disclosed herein do not express one or more MHC-I and MHC-II human leukocyte antigens. Similarly, in certain embodiments, the universal donor stem cells disclosed herein do not express one or more human leukocyte antigens (e.g., HLA-A, HLA-B and/or HLA-C) corresponding to MHC-I and MHC-II human leukocyte antigens, thereby rendering such cells hypoimmunogenic.
