MEISSNER, Torsten, B.,FERREIRA, Leonardo, M.R.,STROMINGER, Jack, L.,COWAN, Chad, A.
申请号：
EP16793348
公开号：
EP3294342A4
申请日:
2016.05.09
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
Disclosed herein are universal donor stem cells and related methods of their use and production. The universal donor stem cells disclosed herein are useful for overcoming the immune rejection in cell-based transplantation therapies. In certain embodiments, the universal donor stem cells disclosed herein do not express one or more MHC-I and MHC-II human leukocyte antigens. Similarly, in certain embodiments, the universal donor stem cells disclosed herein do not express one or more human leukocyte antigens (e.g., HLA-A, HLA-B and/or HLA-C) corresponding to MHC-I and MHC-II human leukocyte antigens, thereby rendering such cells hypoimmunogenic.
